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KMID : 0811720040080000196
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Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.196 ~ p.0
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Effects of Prostaglandin E1 on Endocrine Cardiac Function
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Kim Hyun-Soon
Quan He Xiu
Kim Sung-Zoo
Kim Sun-Hee
Cho Kyung-Woo
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Abstract
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cAMP and cGMP are negative regulators in the regulation of atrial natriuretic peptide (ANP) release. Recently, it was shown that cyclic nucleotides are compartmentalized in the regulation of atrial myocytic ANP release, in that phosphodiesterase (PDE) 3 but not PDE4 is involved in the cAMP-induced decrease in ANP release. Also, particulate guanylyl cyclase (GC) but not soluble GC activation is closely related to the cGMP-induced decrease in ANP release. The purpose of the present study was to define the effect of prostaglandin E1 (PGE1) on the atrial dynamics, stroke volume and pulse pressure and ANP release. Experiments were performed in perfused rabbit left atria allowing atrial pacing and measurements of changes in atrial volume during contraction (stroke volume), pulse pressure, transmural extracellular fluid translocation, cyclic nucleotides (cAMP, cGMP) efflux, and ANP release. Cyclic nucleotides and ANP in the perfusate were measured by a specific radioimmunoassay. PGE1 increased atrial cAMP and cGMP efflux with a minor effect on atrial dynamics. PGE1 has minor effect on atrial ANP release. These findings suggest that PGE1-induced cAMP and cGMP are compartmentalized in the regulation of atrial ANP release.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S143-S143
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KEYWORD
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Atrial natriuretic peptide, Atrium, cAMP, Prostaglandin E1
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